The HPV genome, a double-stranded DNA molecule, consists of 8 kilobase pairs (kbp) of nucleotides, which comprises 3 regions: 6 early open reading frames (ORFs)-E1, E2, E4, E5, E6, and E7 2 late ORFs-L1 and L2 and an upstream regulatory region. About 200 different strains of HPV identified, based on DNA homology, have been found to be etiologically linked to cervical, vaginal, vulvar, penile, anal, oral, and plantar infectious lesions and cancers, as well. Human papillomavirus (HPV), a virus from the papillomavirus family, is capable of infecting humans. Keywords: comparative modeling, DNA probes, genome, HPV, neoplasms, proteome Affluent information in this reserve could be of help for researchers involved in structural virology, cancer research, drug discovery, and vaccine design. Simultaneous easy expandability and retrieval of the strain-specific data, with a provision for sequence analysis and exploration potential of predicted structures, and easy access for curation and annotation through a range of search options at one platform are a few of its important features.
The Human Papillomavirus Proteome Database (hpvPDB) domiciles proteomic and genomic information on 150 HPV strains sequenced to date. We attempted to design an online reserve with comprehensive information on HPV for the end users desiring the same.
Genomic, proteomic, structural, and disease-related information on HPV is available on the web yet, with trivial annotations and more so, it is not well customized for data analysis, host-pathogen interaction, strain-disease association, drug designing, and sequence analysis, etc. The molecular understanding of HPV proteins has significant connotation for understanding their intrusion in the host and designing novel protein vaccines and anti-viral agents, etc. Human papillomavirus (HPV) infection is the leading cause of cancer mortality among women worldwide.
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